The HighQ-2 is an ultracompact, air-cooled, turn-key, 1045 nm fixed wavelength femtosecond IR laser. It features 1.5 W average power and 250 fs pulse width and highly focusable Gaussian spatial beam profile, making it the perfect laser source for fixed wavelength multiphoton imaging in vivo, micro- and nano-structuring, micro- and nano-surgery, and microdissection applications.