MKS Expands Spectra-Physics Ultrafast Laser Portfolio for Neuroscience and Bio-Imaging Applications

Widely Published InSight X3+ Laser Adds Integrated Attenuation Option

Milpitas, CA – November 8, 2021MKS Instruments, Inc.(NASDAQ: MKSI) announces the expansion of its highly popular Spectra-Physics® InSight® X3+™ tunable ultrafast lasers with the introduction of an integrated attenuation option. This new capability provides on-board, software-controlled adjustment of the output power to augment the built-in automated wavelength and dispersion compensation tuning for added optimization of multiphoton imaging performance.

“With an astounding 950 research publications produced using the InSight family of lasers and over 10,000 citations of these publications, the InSight X3™ and X3+ are recognized as the leading lasers for multiphoton imaging used in live deep tissue imaging for Neuroscience and many other applications,”

says Herman Chui, senior director of marketing for the Light and Motion Division of MKS.
“The new integrated attenuation option is another significant extension of our ultrafast laser portfolio for bio-imaging applications.”

An essential component for hundreds of bio-imaging facilities worldwide, the InSight laser family offers an impressive 680 to 1300 nm wavelength tuning range, and every InSight laser includes DeepSee™ automated dispersion compensation to ensure the shortest pulses are delivered to the sample. The InSight X3+ model offers more than 3 W at the peak of the tuning range and extends into the 900 to 1100 nm range where many biologically impactful fluorophores have their absorption bands. Entirely software controlled, the InSight X3+ with integrated attenuation is fully equipped and ready to be used in a wide array of applications including multiphoton imaging, Stimulated Raman Spectroscopy (SRS), Second Harmonic Generation (SHG) microscopy, Coherent Anti-Stokes Raman Spectroscopy (CARS), and Fluorescence Lifetime Imaging Microscopy (FLIM).

The InSight family of lasers have passed extensive environmental qualification testing, and each laser is subjected to rigorous production tests to ensure high reliability. The InSight lasers are field serviceable to ensure maximum uptime and to eliminate the need to realign the microscope in the unlikely event of a service call.

The InSight X3+ laser with integrated attenuation option will be featured at Neuroscience 2021, which will take place online November 8-11, 2021, and at SPIE BIOS, Moscone Center, San Francisco, CA, January 22-23, 2022. Please visit Spectra-Physics at Neuroscience at virtual booth #2 and at SPIE BIOS booth #927 for a demonstration.

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About MKS Instruments

MKS Instruments, Inc. (NASDAQ: MKSI) enables technologies that transform our world. We deliver foundational technology solutions to leading edge semiconductor manufacturing, advanced electronics and specialty industrial applications. We apply our broad science and engineering capabilities to create instruments, subsystems, systems, process control solutions and specialty chemicals technology that improve process performance, optimize productivity and enable unique innovations for many of the world’s leading technology and industrial companies. Our solutions are critical to addressing the challenges of miniaturization and complexity in advanced device manufacturing by enabling increased power, speed and feature enhancement for optimized connectivity. Our solutions are also critical to addressing ever-increasing performance requirements across a wide array of specialty industrial applications. Additional information can be found at

About the Spectra-Physics Brand

Spectra-Physics is a brand within the MKS Instruments Photonics Solutions Division. The Spectra-Physics product portfolio consists of a broad spectrum of lasers for precision industrial and scientific research applications. Spectra-Physics products combine groundbreaking laser technologies with deep applications expertise to deliver disruptive performance and lower total cost of ownership. From the manufacturing floor and semiconductor fab to the research laboratory, Spectra-Physics lasers enhance our customers’ capabilities and productivity in the semiconductor, industrial technologies, life and health sciences, and research markets. For more information, visit

Company Contacts

Herman Chui
Sr. Director of Product Marketing
Tel: +1 408-980-6996

Helen Chan
Marketing Communications Manager
Tel: +1 408-980-5883